Electrochemical reduction of metronidazole at activated glassy carbon electrode and its determination in pharmaceutical dosage forms

J Pharm Biomed Anal. 1998 Jun;17(2):299-305. doi: 10.1016/s0731-7085(97)00202-1.


A voltammetric method has been developed for the determination of metronidazole in dosage forms. The method is based on the electrochemical reduction of the drug at a glassy carbon electrode activated by applying a new pretreatment. The influence of pH, concentration, scan rate and presence of organic solvent and surfactant has been studied. The current is proportional to the concentration and permits the drug to be determined in the concentration range 2 x 10(-6)-6 x 10(-4) M in Britton-Robinson buffer (pH 10). Furthermore, results obtained by the proposed method have been compared with USP XXIII procedure which involves a HPLC method.

Publication types

  • Comparative Study

MeSH terms

  • Antitrichomonal Agents / analysis*
  • Antitrichomonal Agents / chemistry
  • Electrochemistry
  • Hydrogen-Ion Concentration
  • Metronidazole / analysis*
  • Metronidazole / chemistry
  • Oxidation-Reduction
  • Solutions / analysis
  • Suppositories / analysis
  • Suspensions / analysis
  • Tablets / analysis


  • Antitrichomonal Agents
  • Solutions
  • Suppositories
  • Suspensions
  • Tablets
  • Metronidazole