Translocation 2;11 in a fibroma of tendon sheath

Histopathology. 1998 May;32(5):433-5. doi: 10.1046/j.1365-2559.1998.00390.x.


Aims: To determine whether fibromas of tendon sheath represent a reactive fibrosing process or whether they are neoplastic, we investigated the chromosomes of the proliferating cells. A clonally occurring karyotypic abnormality would be an argument in favour of these fibromas being neoplastic.

Methods and results: A biopsy specimen of a fibroma of tendon sheath was cultured after collagenase exposure leading to dissociation of the tissue. The cultured cells were harvested after 4 days and chromosome analysis done according to standard procedures. Ten out of 20 karyotyped cells showed an identical chromosome abnormality characterized by a t(2;11)(q31-32;q12). The other 10 cells showed a normal 46,XX karyotype.

Conclusion: The clonally occurring chromosome abnormality found in this fibroma of tendon sheath suggests that this proliferation is neoplastic and not a reactive fibrosing process.

Publication types

  • Case Reports

MeSH terms

  • Chromosomes, Human, Pair 11*
  • Chromosomes, Human, Pair 2*
  • Female
  • Fibroma / genetics*
  • Fibroma / pathology
  • Humans
  • Karyotyping
  • Middle Aged
  • Tendons*
  • Translocation, Genetic