Haemolytic-uraemic syndrome outbreak caused by Escherichia coli O111:H-: clinical outcomes

Med J Aust. 1998 Jun 1;168(11):552-5.

Abstract

In South Australia in 1995, we treated 20 children with haemolytic-uraemic syndrome associated with Escherichia coli O111:H-. The source of the outbreak was contaminated locally produced semi-dry fermented sausage (mettwurst). One child died of multiple haemorrhagic cerebral infarcts. Eighteen children required renal dialysis (for a median of 14 days); 12 months after discharge five still had significant impairment of renal function. Other major complications included colonic necrosis (3), cerebral haemorrhage/infarction (3), convulsions (4), and glucose intolerance (2). Although E. coli O111:H- has been associated with sporadic cases of haemolytic-uraemic syndrome, this was the first large outbreak reported in Australia.

MeSH terms

  • Animals
  • Child
  • Child, Preschool
  • Disease Outbreaks*
  • Escherichia coli / isolation & purification*
  • Escherichia coli Infections / complications*
  • Escherichia coli Infections / mortality*
  • Escherichia coli Infections / therapy
  • Female
  • Hemolytic-Uremic Syndrome / microbiology*
  • Hemolytic-Uremic Syndrome / mortality*
  • Hemolytic-Uremic Syndrome / therapy
  • Humans
  • Infant
  • Length of Stay
  • Male
  • Meat Products / microbiology*
  • South Australia / epidemiology
  • Swine
  • Treatment Outcome