Chromatin-remodeling factors: machines that regulate?

Curr Opin Cell Biol. 1998 Jun;10(3):346-53. doi: 10.1016/s0955-0674(98)80010-0.


Chromatin has shifted into the focus of attention as a key to understanding the regulation of nuclear processes such as transcription. Protein machines have been described that use the energy of ATP to render chromatin dynamic and hence active, but which may also be involved in chromatin assembly. The discovery of three different Drosophila nucleosome remodeling complexes that contain imitation switch (ISWI), an ATPase with a high degree of sequence conservation from yeast to human, points to a central function of this ATPase in chromatin dynamics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine Triphosphatases / metabolism*
  • Animals
  • Chromatin / genetics*
  • Gene Expression Regulation / physiology*
  • Humans
  • Transcription Factors / metabolism*


  • Chromatin
  • Transcription Factors
  • Adenosine Triphosphatases