Locus Control Regions, Chromatin Activation and Transcription

Curr Opin Cell Biol. 1998 Jun;10(3):361-5. doi: 10.1016/s0955-0674(98)80012-4.


The past year has seen interesting advances in our understanding of the action of locus control regions. For the first time, the chromosomal distance was described in detail as a parameter in positive/negative regulation of transcription via gene competition. A number of publications have also described negative regulatory elements which restrict the action of locus control regions and other regulatory regions to specific genes and/or specific tissues. The emerging picture indicates that several very different types of negative regulation ensure that transcriptional activation occurs only in the appropriate cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Chromatin / genetics*
  • Humans
  • Locus Control Region / physiology*
  • Transcriptional Activation / genetics*


  • Chromatin