Removal of morphine with the new high-efficiency and high-flux membranes during haemofiltration and haemodialfiltration

Nephrol Dial Transplant. 1998 Jun;13(6):1535-7. doi: 10.1093/ndt/13.6.1535.


We present three critically ill patients with severe renal failure who required haemofiltration or haemodiafiltration, with high-efficiency or high-flux membranes, while receiving an intravenous infusion of morphine. We show that despite the very high ultrafiltrability/diffusability of free morphine, only 1-3% of the total amount of infused morphine is removed in 24 h. This is in marked contrast to haemodialysis where, owing to much higher dialysate flow rate, a significant quantity of free morphine is removed.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / blood
  • Acute Kidney Injury / drug therapy
  • Acute Kidney Injury / therapy
  • Adult
  • Critical Illness
  • Female
  • Hemodiafiltration / instrumentation
  • Hemodiafiltration / methods*
  • Hemofiltration / instrumentation
  • Hemofiltration / methods*
  • Humans
  • Infusions, Intravenous
  • Male
  • Metabolic Clearance Rate
  • Middle Aged
  • Morphine / administration & dosage
  • Morphine / blood
  • Morphine / isolation & purification*


  • Morphine