Ischemia/reperfusion injury in flow-through venous flaps

Ann Plast Surg. 1998 Jun;40(6):612-6. doi: 10.1097/00000637-199806000-00007.

Abstract

The effects of ischemia/reperfusion (I/R) injury in flow-through venous flaps were evaluated in rabbits. The rates of flap survival and the levels of lipid peroxidation, protein oxidation, and sulfhydryl groups were compared between flow-through venous flaps, conventional flaps after an I/R period (experimental groups), and flow-through venous flaps without being subjected to I/R injury (control groups) in 20 animals. On the seventh day after the onset of reperfusion, 3 of 10 flow-through venous flaps (30%) and 6 of 10 arteriovenous flaps (60%) survived in the experimental groups. Flow-through venous flaps showed a decreased survival rate compared with control and conventional flaps (p < 0.05). Tissue lipid peroxide levels were found to be higher in venous flaps during reperfusion after secondary ischemia (p < 0.05). Tissue protein oxidation and total sulfhydryl groups levels did not show any difference among groups. This study suggests that more free radical damage occurs in flow-through venous flaps during I/R injury.

MeSH terms

  • Animals
  • Lipid Peroxidation
  • Necrosis
  • Rabbits
  • Reperfusion Injury / physiopathology*
  • Surgical Flaps* / blood supply*
  • Surgical Flaps* / pathology
  • Surgical Flaps* / physiology