Ribosomal Protein Structures: Insights Into the Architecture, Machinery and Evolution of the Ribosome

Trends Biochem Sci. 1998 Jun;23(6):208-12. doi: 10.1016/s0968-0004(98)01214-6.


Models of the bacterial ribosome based on recent structural analyses are beginning to provide new insights into the protein synthetic machinery. Central to evolving models are the high-resolution structures of individual ribosomal proteins, which represent detailed probes of their local RNA and protein environments. Ribosomal proteins are extremely ancient molecules; the structures therefore also provide a unique window into early protein evolution. Many of the proteins contain domains that are present in more recently evolved families of RNA- and DNA-binding proteins. Such structural homology can be used to predict mechanisms by which proteins interact with RNA in the ribosome.

Publication types

  • Review

MeSH terms

  • Bacteria / ultrastructure*
  • Evolution, Molecular
  • Models, Molecular
  • Protein Conformation
  • Ribosomal Proteins / chemistry*
  • Ribosomes / chemistry*
  • Ribosomes / ultrastructure*


  • Ribosomal Proteins