Interleukin-10 as a regulatory cytokine induced by cellular stress: molecular aspects

Int Rev Immunol. 1998;16(5-6):501-22. doi: 10.3109/08830189809043006.


Interleukin-10 is an ubiquitous cytokine which plays a major regulatory role in the course of inflammatory responses by downregulating the synthesis of cytokines. In this paper, we summarize the major biological properties of IL-10 and the current knowledge of the molecular mechanisms by which IL-10 inhibits the expression of genes encoding proinflammatory cytokines. We then review the factors upregulating IL-10 synthesis and we present the concept that IL-10 is a stress cytokine produced not only in response to microbial pathogens but also to cellular injuries of diverse origins.

Publication types

  • Review

MeSH terms

  • Animals
  • Cytokines / biosynthesis*
  • Humans
  • Interleukin-10 / biosynthesis*
  • Interleukin-10 / immunology


  • Cytokines
  • Interleukin-10