Abstract
Some cyclophosphamide toxic effects on lung tissue are presented. Cyclophosphamide metabolism, pathogenesis of lung damage and morphological lung tissue changes caused by that agent were characterized. Attention was focused on BAL evaluation as a useful method in the monitoring of lung tissue damage degree.
MeSH terms
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Animals
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Antineoplastic Agents, Alkylating / adverse effects
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Antineoplastic Agents, Alkylating / metabolism
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Antineoplastic Agents, Alkylating / toxicity*
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Biotransformation
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Cyclophosphamide / adverse effects
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Cyclophosphamide / metabolism
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Cyclophosphamide / toxicity*
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Humans
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Lung / drug effects*
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Lung / ultrastructure
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Pulmonary Fibrosis / chemically induced*
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Pulmonary Fibrosis / pathology
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Rats
Substances
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Antineoplastic Agents, Alkylating
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Cyclophosphamide