Guillain-Barré Syndrome: MR Imaging Findings of the Spine in Eight Patients

Radiology. 1998 Jul;208(1):137-41. doi: 10.1148/radiology.208.1.9646804.

Abstract

Purpose: To evaluate magnetic resonance (MR) imaging findings of the spine in patients with Guillain-Barré syndrome.

Materials and methods: MR imaging findings in eight patients (three male, five female; age range, 2-47 years) with Guillain-Barré syndrome were retrospectively reviewed. Guillain-Barré syndrome was diagnosed mainly on the basis of symptoms and also on the basis of supportive ancillary data, such as the results cerebrospinal fluid analysis and electrophysiologic evaluation. In addition, follow-up MR imaging was performed in three patients, who had slight clinical improvement.

Results: All patients had thickening of the intrathecal spinal nerve roots and cauda equina, with varying degrees of enhancement on gadolinium-enhanced axial T1-weighted images. Two enhancement patterns were noted. One was enhancement of both the anterior and posterior spinal nerve roots (n = 2); the other was enhancement of the anterior spinal nerve roots only (n = 6). Follow-up MR imaging in the three patients with slight improvement of symptoms revealed that the thickening and the degree of enhancement of the spinal nerve roots were diminished.

Conclusion: Although the enhancement of the intrathecal spinal nerve roots is not specific to Guillain-Barré syndrome and can be seen in neoplasia and other inflammatory processes, the enhancement of only the anterior spinal nerve roots is strongly suggestive of Guillain-Barré syndrome.

MeSH terms

  • Adolescent
  • Adult
  • Cauda Equina / pathology
  • Cauda Equina / physiopathology
  • Child
  • Child, Preschool
  • Contrast Media
  • Electrodiagnosis
  • Female
  • Follow-Up Studies
  • Gadolinium DTPA
  • Humans
  • Image Enhancement
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Motor Neurons / physiology
  • Muscle Weakness / physiopathology
  • Neural Conduction / physiology
  • Polyradiculoneuropathy / cerebrospinal fluid
  • Polyradiculoneuropathy / diagnosis
  • Polyradiculoneuropathy / pathology*
  • Polyradiculoneuropathy / physiopathology
  • Retrospective Studies
  • Spinal Nerve Roots / pathology*
  • Spinal Nerve Roots / physiopathology

Substances

  • Contrast Media
  • Gadolinium DTPA