Onset age-dependent variations of three islet specific autoantibodies in Japanese IDDM patients

Diabetes Res Clin Pract. 1998 Mar;39(3):211-7. doi: 10.1016/s0168-8227(98)00008-4.


The age related incidence rate of insulin-dependent diabetes mellitus shows a bimodal distribution, not only in Caucasians but also in Japanese. To evaluate the onset age-related autoimmune profile at presentation in insulin-dependent diabetes mellitus (IDDM), glutamic acid decarboxylase (GAD) autoantibody, islet cell antibody (ICA), and insulin autoantibody (IAA) were measured in 137 newly diagnosed Japanese IDDM patients with onset ages between 0-29 years. The prevalence of GAD autoantibody was significantly increased from the lowest (32%) in the 0-5 years onset age group to 75% in the 13-19 years onset age group (P < 0.05), whereas the IAA prevalence significantly decreased from the peak (48%) in the 6-12 years onset age group to 10% in the 20-29 years onset age group (P < 0.05). The ICA prevalence was increased from the lowest (32%) in the 0-5 years onset age group to the highest (53%) in the 20-29 years onset age group similar to that for the GAD autoantibody. Such results demonstrate that there was age-related autoimmune characteristics at presentation of IDDM in Japanese as well as in Caucasians.

MeSH terms

  • Adolescent
  • Adult
  • Age of Onset
  • Asian Continental Ancestry Group
  • Autoantibodies / analysis*
  • Child
  • Diabetes Mellitus, Type 1 / immunology*
  • Female
  • Glutamate Decarboxylase / immunology*
  • Humans
  • Insulin Antibodies / analysis*
  • Islets of Langerhans / immunology*
  • Japan
  • Male
  • Prevalence
  • Thyroglobulin / immunology


  • Autoantibodies
  • Insulin Antibodies
  • Thyroglobulin
  • Glutamate Decarboxylase