Mammalian and Drosophila dachshund genes are related to the Ski proto-oncogene and are expressed in eye and limb

Mech Dev. 1998 Jun;74(1-2):121-31. doi: 10.1016/s0925-4773(98)00071-9.

Abstract

We have isolated mammalian homologues of the Drosophila dachshund gene. Two domains of high conservation, one of which contains an alpha-helical, coiled-coil motif, show similarity to the Ski family of genes. We therefore propose that Dachshund belongs to a superfamily including these genes. Mouse Dachshund (Dach) is expressed in the eye and limb, structures affected by the Drosophila loss-of-function mutant, and rib primordia, CNS and genital eminence. Pax6 and Dach show overlapping but non-identical expression patterns. Dach expression is unaffected in smalleye mouse brain, indicating that Pax6 is not directly activating Dach. In Drosophila eye development dachshund is a component of an interacting network of proteins. Genes homologous to many of these exist in mammals; Dach joins this expanding group.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Caenorhabditis elegans Proteins / genetics
  • DNA, Complementary / genetics
  • DNA-Binding Proteins / genetics*
  • Drosophila Proteins / biosynthesis
  • Drosophila Proteins / genetics*
  • Drosophila melanogaster / embryology
  • Drosophila melanogaster / genetics*
  • Expressed Sequence Tags
  • Extremities / embryology*
  • Eye / embryology*
  • Eye / metabolism
  • Eye Proteins / biosynthesis
  • Eye Proteins / genetics
  • Fetal Proteins / biosynthesis
  • Fetal Proteins / genetics*
  • Gene Expression Regulation, Developmental*
  • Genitalia / embryology
  • Genitalia / metabolism
  • Homeodomain Proteins / biosynthesis
  • Homeodomain Proteins / genetics
  • Humans
  • In Situ Hybridization
  • Leg / embryology
  • Mice
  • Mice, Mutant Strains
  • Molecular Sequence Data
  • Morphogenesis
  • Multigene Family*
  • Nerve Tissue Proteins / biosynthesis
  • Nerve Tissue Proteins / genetics
  • Nervous System / embryology
  • Nervous System / metabolism
  • Nuclear Proteins / biosynthesis
  • Nuclear Proteins / genetics*
  • Organ Specificity
  • PAX6 Transcription Factor
  • Paired Box Transcription Factors
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogenes*
  • Repressor Proteins
  • Ribs / embryology
  • Ribs / metabolism
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Species Specificity

Substances

  • Caenorhabditis elegans Proteins
  • DNA, Complementary
  • DNA-Binding Proteins
  • Drosophila Proteins
  • Eye Proteins
  • Fetal Proteins
  • Homeodomain Proteins
  • Nerve Tissue Proteins
  • Nuclear Proteins
  • PAX6 Transcription Factor
  • PAX6 protein, human
  • Paired Box Transcription Factors
  • Pax6 protein, mouse
  • Proto-Oncogene Proteins
  • Repressor Proteins
  • Ski protein, mouse
  • dac protein, Drosophila
  • SKI protein, human

Associated data

  • GENBANK/AJ005669
  • GENBANK/AJ005670