Elevated Plasma Levels of Transforming Growth Factor (TGF)-beta1 and TGF-beta2 in Patients With Disseminated Malignant Melanoma

Br J Cancer. 1998 May;77(9):1492-4. doi: 10.1038/bjc.1998.245.

Abstract

Overexpression of transforming growth factor-beta isoforms (TGF-beta1, -beta2, -beta3) has been previously reported in human melanoma cell lines and tumours. The aim of the present study was to evaluate the plasma levels of TGF-beta isoforms in melanoma patients. Significantly elevated levels of TGF-beta1 (4.2 x the controls, P = 0.0094) and of TGF-beta2 (1.5 x the controls, P = 0.012) but not of TGF-beta3 were measured in patients with disseminated but not locoregional melanoma. These results indicate systemic circulation of potentially immunosuppressive peptides of the TGF-beta family in end-stage melanoma patients.

MeSH terms

  • Humans
  • Lymphatic Metastasis
  • Melanoma / blood*
  • Melanoma / secondary
  • Neoplasm Proteins / blood*
  • Neoplasm Staging
  • Transforming Growth Factor beta / blood*

Substances

  • Neoplasm Proteins
  • Transforming Growth Factor beta