Dismantling in Cell Death: Molecular Mechanisms and Relationship to Caspase Activation

Scand J Immunol. 1998 Jun;47(6):523-31. doi: 10.1046/j.1365-3083.1998.00363.x.

Abstract

The notion of a cell death programme was introduced in view of the reproducibility of its occurrence in time and space (e.g. in the developing embryo) and of its genetic determination. Programmed cell death can be schematically subdivided into three steps: a signalling phase, an execution phase and a dismantling phase. This review focuses on the latter. Apoptosis is the most studied form of dismantling of animal cells. The molecular pathways leading to certain apoptotic lesions appear to be dependent on the proteolytic activity of caspases. Death itself can, however, be caspase-independent. Also, non-apoptotic forms of cell death exist, even in animal cells; their molecular bases are still unknown. The relationship between cell death, apoptosis and caspases is discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Caenorhabditis elegans Proteins
  • Caspase 3
  • Caspases*
  • Cell Death*
  • Cysteine Endopeptidases / metabolism*
  • Enzyme Activation
  • Humans

Substances

  • Caenorhabditis elegans Proteins
  • CASP3 protein, human
  • Caspase 3
  • Caspases
  • Cysteine Endopeptidases
  • ced-3 protein, C elegans