A novel CXC chemokine PBSF/SDF-1 and its receptor CXCR4: their functions in development, hematopoiesis and HIV infection

Semin Immunol. 1998 Jun;10(3):179-85. doi: 10.1006/smim.1998.0128.

Abstract

PBSF/SDF-1 is a CXC chemokine which has unique functions among chemokines. It is essential for viability of the embryo, B lymphopoiesis, bone marrow hematopoiesis and cardiogenesis. A receptor for PBSF/SDF-1 was shown to be CXCR4 that is an entry co-receptor for T cell line-tropic HIV-1. Although murine cells had been thought to have no functional co-receptors, murine CXCR4 allowed entry of HIV-1 into target cells with human CD4. In addition, a small molecule CXCR4 inhibitor that blocks HIV-1 entry was identified.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • B-Lymphocytes / immunology
  • Cell Lineage / physiology
  • Chemokine CXCL12
  • Chemokines, CXC / physiology*
  • Embryonic and Fetal Development / physiology*
  • HIV Infections / immunology*
  • HIV Infections / physiopathology*
  • HIV-1*
  • Heart / embryology
  • Hematopoiesis / physiology*
  • Humans
  • Molecular Sequence Data
  • Morphogenesis / physiology
  • Receptors, CXCR4 / physiology*

Substances

  • CXCL12 protein, human
  • Chemokine CXCL12
  • Chemokines, CXC
  • Receptors, CXCR4