Small-molecule-based strategies for controlling gene expression

Chem Biol. 1998 Jun;5(6):R129-45. doi: 10.1016/s1074-5521(98)90167-3.


A central goal in chemical biology is to gain control over biological pathways using small molecules, and the mRNA-synthesizing machinery is a particular important target. New advances in our understanding of transcriptional regulation suggests strategies to manipulate these pathways using small molecules.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Drug Design
  • Gene Expression Regulation*
  • Genetic Engineering / methods*
  • Humans
  • Models, Genetic
  • Models, Molecular
  • RNA, Messenger / biosynthesis*


  • RNA, Messenger