Freeze-drying of bioproducts: putting principles into practice

Eur J Pharm Biopharm. 1998 May;45(3):221-9. doi: 10.1016/s0939-6411(98)00004-6.

Abstract

The product and process parameters that determine successful freeze-drying are described and their interrelationships are explored. It is shown that the thermochemical and thermomechanical properties of water-soluble, amorphous materials form the basis of effective formulation design and that coordinated approaches to formulation and process development achieve optimum results with a minimum of trial-and-error experimentation.

Publication types

  • Review

MeSH terms

  • Biological Products / chemistry*
  • Drug Stability
  • Freeze Drying* / methods

Substances

  • Biological Products