Nicotine Metabolism Defect Reduces Smoking

Nature. 1998 Jun 25;393(6687):750. doi: 10.1038/31623.

Publication types

  • Letter

MeSH terms

  • Alleles
  • Aryl Hydrocarbon Hydroxylases*
  • Cytochrome P-450 CYP2A6
  • Cytochrome P-450 Enzyme System / deficiency
  • Cytochrome P-450 Enzyme System / genetics
  • Cytochrome P-450 Enzyme System / metabolism*
  • Gene Frequency
  • Humans
  • Mixed Function Oxygenases / deficiency
  • Mixed Function Oxygenases / genetics
  • Mixed Function Oxygenases / metabolism*
  • Nicotine / metabolism*
  • Smoking / genetics*
  • Tobacco Use Disorder / enzymology*

Substances

  • Nicotine
  • Cytochrome P-450 Enzyme System
  • Mixed Function Oxygenases
  • Aryl Hydrocarbon Hydroxylases
  • Cytochrome P-450 CYP2A6