Is IgG anti-GT1a antibody associated with pharyngeal-cervical-brachial weakness or oropharyngeal palsy in Guillain-Barré syndrome?

J Neuroimmunol. 1998 Jun 1;86(1):74-9. doi: 10.1016/s0165-5728(98)00016-2.


The pharyngeal-cervical-brachial variant (PCB) of Guillain-Barré syndrome (GBS) has clinical features similar to those of botulism and diphtheria. Mizoguchi et al. (1994) [Mizoguchi, K., Hase, A., Obi, T., Matsuoka, H., Takatsu, M., Nishimura, Y., Irie, F., Seyama, Y., Hirabayashi, Y., 1994. Two species of antiganglioside antibodies in a patient with a pharyngeal-cervical-brachial variant of Guillain-Barré syndrome. J. Neurol. Neurosurg. Psychiatry 57, 1121-1123] reported a patient with PCB-like symptoms who had serum IgG anti-GT1a antibodies which did not cross-react with GQ1b. We assumed that PCB is associated with anti-GT1a antibodies that do not have reactivity to GQ1b and made a serological study of a PCB patient. We searched for PCB patients prospectively and found one with PCB. This patient had IgG anti-GT1a antibodies which were not absorbed with GQ1b in an absorption study, whereas IgG anti-GT1a antibodies from Fisher's syndrome patients were. The frequency of positive IgG anti-GT1a antibody did not differ in patients with and without bulbar palsy. Our findings indicate that IgG anti-GT1a antibodies which do not cross-react with GQ1b are specifically detectable in PCB and can be used as a diagnostic marker of PCB.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Autoantibodies / analysis*
  • Brachial Plexus / immunology
  • Brachial Plexus / physiopathology
  • Bulbar Palsy, Progressive / immunology*
  • Cervical Plexus / immunology
  • Cervical Plexus / physiopathology
  • Cross Reactions
  • Enzyme-Linked Immunosorbent Assay
  • Gangliosides / immunology*
  • Humans
  • Immunoglobulin G / analysis
  • Male
  • Nerve Growth Factors / immunology
  • Pharyngeal Muscles / immunology
  • Pharyngeal Muscles / innervation
  • Pharyngeal Muscles / physiopathology
  • Polyradiculoneuropathy / immunology*
  • Prospective Studies


  • Autoantibodies
  • Gangliosides
  • Immunoglobulin G
  • Nerve Growth Factors
  • trisialoganglioside GT1
  • GQ1b ganglioside