Study on cockroach antigen as a probable causative agent in bronchial asthma

J Allergy Clin Immunol. 1976 Sep;58(3):357-65. doi: 10.1016/0091-6749(76)90115-9.


Bronchial provocative test (BPT) with cockroach (CR) antigen was performed in 22 asthmatic subjects. Sixteen had positive reaction (CR-positive) and 6 had negative reaction (CR-negative) to CR antigen by skin test. Immediate bronchoconstrictive response was noted following the antigen inhalation in 14 of 16 CR-positive asthmatics, while none of 6 CR-negative asthmatics showed bronchospasm. Late asthmatic responses also were noted in 13 of 16 CR-positive asthmatic individuals following BPT with CR antigen. The dual asthmatic reactions in CR-positive individuals were mostly inhibited by the prior administration of cromolyn sodium. Three-fold increases in peripheral eosinophil counts were noted 24 hr following BPT with CR antigen. Results indicate that CR-induced asthmatic responses are allergen-specific and CR plays a causative role in allergic asthma in the population studied.

MeSH terms

  • Adolescent
  • Adult
  • Antigens*
  • Asthma / diagnosis
  • Asthma / etiology*
  • Child
  • Cockroaches / immunology*
  • Eosinophils
  • Humans
  • Leukocyte Count
  • Middle Aged
  • Respiratory Function Tests
  • Skin Tests
  • Time Factors


  • Antigens