The effect of sodium lauryl sulfate on recurrent aphthous ulcers: a clinical study

Compend Contin Educ Dent. 1997 Dec;18(12):1238-40.


This study measured the incidence of recurrent aphthous ulcers during the use of dentifrices with and without sodium lauryl sulfate (SLS). A single-blind, crossover design was used. A statistically significant reduction in recurrent aphthous ulcers was observed during 2 months' use of SLS-free dentifrice compared to 2 months' use of the SLS-containing dentifrice. These results support the results of an earlier independent study, and suggest that use of an SLS-free dentifrice should be considered for individuals suffering from recurrent aphthous ulcers.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Cross-Over Studies
  • Dentifrices / adverse effects*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Single-Blind Method
  • Sodium Dodecyl Sulfate / adverse effects*
  • Stomatitis, Aphthous / chemically induced*
  • Surface-Active Agents / adverse effects*


  • Dentifrices
  • Surface-Active Agents
  • Sodium Dodecyl Sulfate