Albendazole plus praziquantel versus albendazole alone as a pre-operative treatment in intra-abdominal hydatisosis caused by Echinococcus granulosus

Trop Med Int Health. 1998 Jun;3(6):462-6. doi: 10.1046/j.1365-3156.1998.00257.x.


Objective: To compare the effects of a combined medication of albendazole (10 mg/kg/day) plus praziquantel (25 mg/kg/day) to those of albendazole alone at different doses (10 and 20 mg/kg/day).

Method: The protoscoleces' viability was studied in a consecutive series of patients affected by intra-abdominal hydatidosis caused by Echinococcus granulosus. In all cases the drugs were given during the month prior to surgery.

Results: A significant increase of patients with nonviable protoscoleces was observed in the group treated with the scolicides combination compared to those treated with albendazole alone, both at a dose of 10 mg/kg/day (P = 0.004) and at a dose of 20 mg/kg/day (P = 0.03). Albendazole sulphoxide levels in serum and in cyst fluid were higher in patients given the combined therapy than in those who received only albendazole (10 mg/kg/day: P = 0.016; 20 mg/kg/day: P = 0.034). Levels in the cysts were not significantly different probably due to the sample size; nevertheless a lineal relation between the values obtained in serum and inside the cysts could be discerned in the patients treated with the combined medication.

Conclusion: Albendazole plus praziquantel is more effective than monotherapy with albendazole in the preoperative treatment of intra-abdominal hydatidosis.

MeSH terms

  • Abdomen / parasitology*
  • Adult
  • Aged
  • Albendazole / therapeutic use*
  • Anthelmintics / therapeutic use*
  • Antiplatyhelmintic Agents / therapeutic use
  • Drug Therapy, Combination
  • Echinococcosis / drug therapy*
  • Echinococcosis, Hepatic / drug therapy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Praziquantel / therapeutic use*


  • Anthelmintics
  • Antiplatyhelmintic Agents
  • Praziquantel
  • Albendazole