A systematic study of the lactate lineshape in PRESS-localized proton spectroscopy

Magn Reson Med. 1998 Jul;40(1):72-8. doi: 10.1002/mrm.1910400111.


J-coupled resonances such as lactate exhibit complex behavior in PRESS-localized spectroscopy. Polarization transfer effects due to nonideal slice profiles can lead to substantial errors in quantification unless recognized. In this work, it is shown how these effects can be predicted in a systematic way given the sequence timing and the RF pulse envelopes. Experimental results are presented to highlight the problems of working at the popular echo time of 2/J.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Image Enhancement / methods*
  • Lactic Acid / analysis*
  • Magnetic Resonance Spectroscopy / instrumentation
  • Magnetic Resonance Spectroscopy / methods*
  • Models, Structural*
  • Phantoms, Imaging
  • Protons
  • Sensitivity and Specificity


  • Protons
  • Lactic Acid