This paper reports the preliminary results of research investigating the factors that help or hinder advanced nurse practitioners as they attempt to implement new roles in clinical practice. Multiple facilitating and inhibiting factors are identified, the majority of which are shared across various clinical settings. Factors fall into three categories: re-negotiating relationships; becoming an advanced practitioner; and the clinical context and deployment. Whilst the results of this case study research are not necessarily generalizable, they provide evidence of the lived experience of advanced nurse practitioners attempting to implement new roles in a variety of clinical settings following their graduation from a Master's degree programme.