Prostatectomy tissue for research: balancing patient care and discovery

Am J Clin Pathol. 1998 Jul;110(1):4-9. doi: 10.1093/ajcp/110.1.4.


The application of modern technology in basic research often requires fresh tissue from human organs. The acquisition of this tissue challenges the anatomic pathologist to balance the needs of the basic scientist with the requirements of quality patient care. Our experience indicates that fresh tissue adequate for research can be obtained from neoplastic prostate glands without compromising patient care. The process requires dedicated, knowledgeable individuals and extensive documentation. Potential problems include low yield for research studies, loss of all residual carcinoma, compromise of the specimen margin, and unforeseen costs. Best collaborations occur in situations in which basic scientists and anatomic pathologists establish a working relationship and develop a mutually supportive means of funding.

MeSH terms

  • Antineoplastic Agents, Hormonal / therapeutic use
  • Humans
  • Leuprolide / therapeutic use
  • Male
  • Patient Care*
  • Prostatectomy*
  • Prostatic Neoplasms / drug therapy
  • Prostatic Neoplasms / genetics
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / surgery*
  • RNA, Neoplasm / analysis
  • Research Design
  • Specimen Handling / economics
  • Specimen Handling / methods*


  • Antineoplastic Agents, Hormonal
  • RNA, Neoplasm
  • Leuprolide