Baló's concentric sclerosis in a 4-year-old Japanese infant

Brain Dev. 1998 Jun;20(4):250-2. doi: 10.1016/s0387-7604(98)00025-4.


We report the youngest known case with Baló's concentric sclerosis (Baló's disease), a variant of multiple sclerosis. This 4-year-old Japanese boy was diagnosed by clinical manifestations and by characteristic findings on magnetic resonance imaging (MRI). Dexamethasone was given intravenously, 3 mg twice daily for 10 days. The clinical manifestations were resolved within 2 weeks, and the MRI findings were markedly improved after 3 weeks. Following the initiation of steroid therapy, he showed remarkable clinical and physical improvement. It cannot be excluded that the clinical improvement resulted from the steroid therapy.

Publication types

  • Case Reports

MeSH terms

  • Brain / pathology
  • Child, Preschool
  • Dexamethasone / therapeutic use
  • Diffuse Cerebral Sclerosis of Schilder / diagnosis*
  • Diffuse Cerebral Sclerosis of Schilder / drug therapy*
  • Diffuse Cerebral Sclerosis of Schilder / physiopathology
  • Glucocorticoids / therapeutic use*
  • Humans
  • Injections, Intravenous
  • Japan
  • Magnetic Resonance Imaging
  • Male
  • Treatment Outcome


  • Glucocorticoids
  • Dexamethasone