A staging system for forelimb regeneration in the axolotl, Ambystoma mexicanum

J Morphol. 1976 Sep;150(1):117-28. doi: 10.1002/jmor.1051500106.


A staging system has been devised for normal regeneration from the upper arm in the mature axolotl. It consists of seven externally definable stages: (1) Wound healing (WH): (2) Dedifferentiation (DD); (3) Early bud (EB); (4) Medium bud (MB); (5) Late bud (LB); (6) Palette (Pal), and (7) Digital outgrowth (DO). Serial histological sections of 38 regenerating limbs were used to correlate gross stages with microscopic events in the regenerative process.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Ambystoma / physiology*
  • Animals
  • Bone Regeneration
  • Forelimb / physiology*
  • Regeneration*
  • Skin / anatomy & histology
  • Skin Physiological Phenomena
  • Terminology as Topic
  • Time Factors
  • Wound Healing