Differential effects of intracerebroventricular glucagon-like peptide-1 on feeding and energy expenditure regulation

Peptides. 1998;19(5):869-75. doi: 10.1016/s0196-9781(98)00033-3.


Intracerebroventricular (i.c.v.) administration of glucagon-like peptide-1-(7-37) amide (GLP-1) has been shown to modulate food and water intake. The present studies further characterize the effects of i.c.v. GLP-1 in the regulation of energy balance in lean and obese animals. In both obese and lean Zucker rats, a single i.c.v. infusion of GLP-1 (1-30 microg) resulted in a dose-dependent reduction of food intake and decrease in respiratory quotient relative to the saline control during the first 2 h of the nocturnal cycle. In obese Zucker rats, the food intake was reduced by 73 +/- 11% of the control at the 30 microg dose, whereas a modest 45 +/- 18% reduction was observed in lean rats. Despite the large reduction in food intake seen with GLP-1, there was no compensatory decrease in nocturnal oxygen consumption in the obese Zucker rats. Interestingly, low doses of GLP-1 (1 microg) in lean Zucker rats, which had minimal effects on food intake, caused a 19 +/- 7% increase in O2 consumption during the first 2 h of the nocturnal cycle. These data suggest that central GLP-1 may be an important factor controlling negative energy balance in both the lean and obese Zucker rats.

Publication types

  • Comparative Study

MeSH terms

  • Analysis of Variance
  • Animals
  • Drinking Behavior / drug effects*
  • Energy Metabolism / drug effects*
  • Feeding Behavior / drug effects*
  • Glucagon / pharmacology*
  • Glucagon-Like Peptide 1
  • Injections, Intraventricular
  • Male
  • Obesity / genetics*
  • Peptide Fragments / pharmacology*
  • Protein Precursors / pharmacology*
  • Rats
  • Rats, Zucker


  • Peptide Fragments
  • Protein Precursors
  • Glucagon-Like Peptide 1
  • Glucagon