Growth phase coupled modulation of Escherichia coli ribosomes

Genes Cells. 1998 Apr;3(4):203-8. doi: 10.1046/j.1365-2443.1998.00187.x.


Ribosomal modulation factor (RMF), a small basic protein, expresses transcriptionally in the stationary phase of Escherichia coli cells and binds to 50S ribosomal subunits. The RMF bound 70S ribosomes dimerize to form 100S particles that have no translational activity. In transferring the stationary cells to a fresh medium, the 100S particles release the RMF and dissociate to active 70S. The interconversion of ribosomes between active 70S and inactive 100S by RMF is a cellular mechanism controlling translation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Escherichia coli / growth & development*
  • Escherichia coli Proteins*
  • Protein Biosynthesis*
  • Ribosomal Proteins / metabolism*
  • Ribosomes / metabolism*
  • Ribosomes / ultrastructure


  • Escherichia coli Proteins
  • Ribosomal Proteins
  • ribosome modulation factor, E coli