Clinical expression of autoimmune diseases in older adults

Clin Geriatr Med. 1998 Aug;14(3):515-42.


Aging modifies the clinical presentation and course of autoimmune disorders. In the older person who carries a complement of predisposing genes, environmental factors may alter a senescent immune system and trigger the onset of autoimmunity. In this article about autoimmune diseases of the older adult, the authors discuss the epidemiology, clinical presentations, laboratory and radiographic findings, and management of systemic lupus erythematosus, primary Sjogren's syndrome, and idiopathic inflammatory myopathies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Aged
  • Autoimmune Diseases* / epidemiology
  • Female
  • Humans
  • Lupus Erythematosus, Systemic* / epidemiology
  • Male
  • Middle Aged
  • Polymyositis* / epidemiology
  • Sjogren's Syndrome* / epidemiology