[Absorption and metabolism of glycerin in the neonatal period. I. Speed of turnover of glycerin during continuous intravenous infusions in newborn infants of various gestational ages and in older infants]

Abstract

Glycerol was infused intravenously over 2 hours in preterm and term appropriate-for-date and in term small-for-date infants at the age of 12 to 72 hours and 10 to 14 days and in infants at the age of 3 to 8 months. The dosage was 0.25.kg-1.h-1 and 0.5.kg-1.h-1, respectively. Less than 6 per cent of the glycerol injused were recovered in the urine irrespective of the dosage. The total clearance was 9.1 to 14.6 ml.kg-1. min-1 during the first weeks of life with 0.25 g.kg-1.h-1 glycerol irrespective of gestational age and intra-uterine growth retardation; and it rose to 31.8 ml.kg-1.min-1 in older infants. With 0.5.kg-1.h-1 glycerol the total clearance values were lower in all groups. The glucose blood level and the blood lactate concentration as well as the parameters of the acid-base-balance were not significantly influenced by glycerol.