Olfactory and intranasal trigeminal event-related potentials in anosmic patients

Laryngoscope. 1998 Jul;108(7):1033-5. doi: 10.1097/00005537-199807000-00015.


The aim of this study was to investigate the usefulness of chemosensory event-related potentials (CSERPs) in response to both olfactory and intranasal trigeminal stimulation in the diagnosis of anosmia. Forty-four patients participated. Gaseous CO2 was used for trigeminal stimulation, vanillin and H2S were used as olfactory stimulants. Event-related potentials to olfactory stimuli could not be obtained in any of the anosmic patients, indicating the complete loss of the sense of smell. However, all patients responded to stimulation of the trigeminal nerve with CO2. These data clearly demonstrate the clinical significance of CSERPs in the assessment of anosmia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Benzaldehydes
  • Carbon Dioxide
  • Electroencephalography*
  • Evoked Potentials*
  • Female
  • Humans
  • Hydrogen Sulfide
  • Male
  • Middle Aged
  • Olfaction Disorders / diagnosis*
  • Olfaction Disorders / etiology
  • Olfaction Disorders / physiopathology*
  • Olfactory Nerve / physiopathology*
  • Reproducibility of Results
  • Stimulation, Chemical*
  • Trigeminal Nerve / physiopathology*


  • Benzaldehydes
  • Carbon Dioxide
  • vanillin
  • Hydrogen Sulfide