Comparative in vitro activity of BAY 12-8039 and five other antimicrobial agents against anaerobic bacteria

Eur J Clin Microbiol Infect Dis. 1998 Mar;17(3):193-5. doi: 10.1007/BF01691117.

Abstract

The in vitro activity of BAY 12-8039 against 360 anaerobic clinical isolates was determined by the agar dilution method and compared to that of five other antimicrobial agents. BAY 12-8039 and imipenem were the most active agents tested. The following MIC90 values were determined for BAY 12-8039: Peptostreptococcus spp. (50 isolates), 1 mg/l; Propionibacterium acnes (30 isolates). 0.25 mg/l; Clostridium perfringens (30 isolates), 0.5 mg/l; Clostridium difficile (50 isolates), 2 mg/l; Bacteroides fragilis (50 isolates), 1 mg/l; non-fragilis Bacteroides, Porphyromonas, and Prevotella spp. (100 isolates), 2 mg/l; and Fusobacterium spp. (50 isolates), 0.25 mg/l. The results of the present study show that BAY 12-8039 may be useful in the treatment and prophylaxis of anaerobic infections.

Publication types

  • Comparative Study

MeSH terms

  • Anti-Infective Agents / pharmacology*
  • Aza Compounds*
  • Bacteria, Anaerobic / drug effects*
  • Cefoxitin / pharmacology
  • Cephamycins / pharmacology
  • Clindamycin / pharmacology
  • Fluoroquinolones*
  • Imipenem / pharmacology
  • Metronidazole / pharmacology
  • Moxifloxacin
  • Ofloxacin / pharmacology
  • Quinolines*
  • Quinolones / pharmacology*
  • Thienamycins / pharmacology

Substances

  • Anti-Infective Agents
  • Aza Compounds
  • Cephamycins
  • Fluoroquinolones
  • Quinolines
  • Quinolones
  • Thienamycins
  • Metronidazole
  • Clindamycin
  • Cefoxitin
  • Imipenem
  • Ofloxacin
  • Moxifloxacin