Trinucleotide repeat DNA structures: dynamic mutations from dynamic DNA

Curr Opin Struct Biol. 1998 Jun;8(3):321-30. doi: 10.1016/s0959-440x(98)80065-1.


Models for the disease-associated expansion of (CTG)n.(CAG)n, (CGG)n.(CCG)n, and (GAA)n.(TTC)n trinucleotide repeats involve alternative DNA structures formed during DNA replication, repair and recombination. These repeat sequences are inherently flexible and can form a variety of hairpins, intramolecular triplexes, quadruplexes, and slipped-strand structures that may be important intermediates and result in their genetic instability.

Publication types

  • Review

MeSH terms

  • Base Composition
  • Base Sequence
  • DNA / chemistry*
  • DNA / genetics*
  • DNA Repair
  • DNA Replication
  • Genetic Diseases, Inborn / genetics
  • Humans
  • Models, Genetic
  • Models, Molecular
  • Mutation*
  • Nucleic Acid Conformation*
  • Recombination, Genetic
  • Thermodynamics
  • Trinucleotide Repeats*


  • DNA