Finding the genes in genomic DNA

Curr Opin Struct Biol. 1998 Jun;8(3):346-54. doi: 10.1016/s0959-440x(98)80069-9.


Genome sequencing efforts will soon generate hundreds of millions of bases of human genomic DNA containing thousands of novel genes. In the past year, the accuracy of computational gene-finding methods has improved significantly, to the point where a reasonable approximation of the gene structures within an extended genomic region can often be predicted in advance of more detailed experimental studies.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • DNA / chemistry*
  • DNA / genetics*
  • Exons
  • Genes*
  • Genetic Techniques
  • Genome, Human
  • Humans
  • Markov Chains
  • Models, Genetic
  • Protein Biosynthesis
  • Repetitive Sequences, Nucleic Acid
  • Transcription, Genetic


  • DNA