Protein fold irregularities that hinder sequence analysis

Curr Opin Struct Biol. 1998 Jun;8(3):364-71. doi: 10.1016/s0959-440x(98)80071-7.


The detection of homologous protein sequences frequently provides useful predictions of function and structure. Methods for homology searching have continued to improve, such that very distant evolutionary relationships can now be detected. Little attention has been paid, however, to the problems of detecting homology when domains are inserted or permuted. Here we review recent occurrences of these phenomena and discuss methods that permit their detection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Evolution, Molecular
  • Humans
  • Models, Molecular
  • Molecular Sequence Data
  • Protein Folding*
  • Protein Structure, Secondary*
  • Proteins / chemistry*
  • Proteins / metabolism*
  • Sequence Alignment
  • Sequence Homology, Amino Acid


  • Proteins