Upper gastrointestinal disease in patients with familial adenomatous polyposis

Br J Surg. 1998 Jun;85(6):742-50. doi: 10.1046/j.1365-2168.1998.00776.x.


Background: Upper gastrointestinal disease has become an important aspect in the management of patients with familial adenomatous polyposis (FAP).

Methods: A review of the literature was carried out using Medline. Epidemiology, pathology and treatment options are considered.

Results and conclusion: Despite the fact that over 90 per cent of patients with FAP develop duodenal adenomas, only 5 per cent go on to develop cancer. In the absence of methods to detect who is at risk of cancer, all patients undergo regular endoscopic surveillance at present. Chemoprevention in the form of drug therapy may be the answer to controlling the disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenomatous Polyposis Coli / complications*
  • Adenomatous Polyposis Coli / epidemiology
  • Adenomatous Polyposis Coli / pathology
  • Bile
  • Duodenal Neoplasms / etiology*
  • Duodenal Neoplasms / genetics
  • Duodenal Neoplasms / therapy
  • Genes, p53 / genetics
  • Humans
  • Mutation
  • Stomach Neoplasms / etiology*
  • Stomach Neoplasms / genetics
  • Stomach Neoplasms / therapy