Engineering enzyme specificity

Curr Opin Chem Biol. 1998 Feb;2(1):127-32. doi: 10.1016/s1367-5931(98)80044-6.


Protein engineering is the application of knowledge to design and alter protein function and structure. Although powerful methods, from specific to random, have been developed for the redesign of protein architecture, their successful application is dependent on the information known about the protein. This database of information is providing a foundation for establishing rules that govern enzyme-substrate interactions.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Enzymes / chemistry*
  • Humans
  • Protein Engineering*
  • Substrate Specificity*


  • Enzymes