Mitogen-activated protein kinase cascades as regulators of stress responses

Ann N Y Acad Sci. 1998 Jun 30;851:139-46. doi: 10.1111/j.1749-6632.1998.tb08987.x.


Mitogen-activated protein kinase (MAPK) cascades play an important role in transducting environmental stimuli to the transcriptional machinery in the nucleus by virtue of their ability to phosphorylate and regulate the activity of various transcription factors. Originally found to be activated in response to occupancy of cell surface receptors for polypeptide hormones, cytokines, and growth factors, MAPK cascades were recently found to be activated by a variety of stresses including ischemia reperfusion, neuronal injury, osmotic shock, and exposure to UV irradiation. Therefore, MAPK cascades are likely to be important regulatory elements in a variety of stress responses.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology
  • Calcium-Calmodulin-Dependent Protein Kinases / physiology*
  • Cell Division / physiology
  • Enzyme Activation / physiology
  • JNK Mitogen-Activated Protein Kinases
  • Mammals
  • Mitogen-Activated Protein Kinases*
  • Signal Transduction / physiology
  • Stress, Physiological / physiopathology*
  • Ultraviolet Rays


  • Calcium-Calmodulin-Dependent Protein Kinases
  • JNK Mitogen-Activated Protein Kinases
  • Mitogen-Activated Protein Kinases