The science and therapy of glucocorticoid-induced bone loss

Endocrinol Metab Clin North Am. 1998 Jun;27(2):465-83. doi: 10.1016/s0889-8529(05)70017-7.


Glucocorticoids are critical in the management of chronic, noninfectious, inflammatory diseases. Bone loss is a most devastating side effect of these powerful medications. Glucocorticoids produce bone loss by altering calcium metabolism, suppressing gonadal hormone production, and inhibiting bone formation. Now that the mechanism of glucocorticoid-induced bone loss is understood and effective medications are available, this disease can be prevented and reversed.

Publication types

  • Review

MeSH terms

  • Bone Density / drug effects
  • Glucocorticoids / adverse effects*
  • Gonadal Steroid Hormones / metabolism
  • Humans
  • Muscles / drug effects
  • Osteoporosis / chemically induced*
  • Osteoporosis / drug therapy
  • Risk Factors


  • Glucocorticoids
  • Gonadal Steroid Hormones