Hepatitis, hyperglycemia, pleural effusion, eosinophilia, hematuria and proteinuria occurring early in clozapine treatment

Int Clin Psychopharmacol. 1998 Mar;13(2):95-8. doi: 10.1097/00004850-199803000-00007.

Abstract

This report describes a 48-year-old caucasian male with schizophrenia who developed hepatitis, hyperglycemia, pleural effusion, eosinophilia, hematuria and proteinuria early in clozapine treatment which resolved on drug discontinuation. The literature on similar cases is reviewed.

Publication types

  • Case Reports

MeSH terms

  • Antipsychotic Agents / adverse effects*
  • Antipsychotic Agents / therapeutic use
  • Blood Cell Count
  • Chemical and Drug Induced Liver Injury / blood
  • Chemical and Drug Induced Liver Injury / diagnostic imaging
  • Chemical and Drug Induced Liver Injury / physiopathology*
  • Clozapine / adverse effects*
  • Eosinophilia / blood
  • Eosinophilia / chemically induced*
  • Eosinophilia / diagnostic imaging
  • Hematuria / blood
  • Hematuria / chemically induced*
  • Hematuria / diagnostic imaging
  • Humans
  • Hyperglycemia / blood
  • Hyperglycemia / chemically induced*
  • Hyperglycemia / diagnostic imaging
  • Male
  • Middle Aged
  • Pleural Effusion / blood
  • Pleural Effusion / chemically induced*
  • Pleural Effusion / diagnostic imaging
  • Proteinuria / blood
  • Proteinuria / chemically induced*
  • Proteinuria / diagnostic imaging
  • Schizophrenia, Paranoid / drug therapy
  • Tomography, X-Ray Computed

Substances

  • Antipsychotic Agents
  • Clozapine