Improved myocardial ischemia detection by combined physical and mental stress testing

Am J Cardiol. 1998 Jul 1;82(1):109-13. doi: 10.1016/s0002-9149(98)00229-x.


The hypothesis that addition of mental stress to physical exercise would modify the circulation response to stress and improve noninvasive detection of myocardial ischemia was tested in a randomized, crossover radionuclide angiocardiographic study. Compared with physical exercise or mental stress alone, combined stress led to higher heart rates and rate-pressure products in early stress stages, to more pronounced symptoms, and to a better discrimination of subjects with and without coronary artery disease by radionuclide angiography.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Cross-Over Studies
  • Diagnosis, Differential
  • Exercise Test / methods*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myocardial Ischemia / diagnostic imaging*
  • Myocardial Ischemia / etiology
  • Myocardial Ischemia / psychology*
  • Radionuclide Imaging
  • Stress, Psychological / complications*