Correlation between anterior chamber IgG/albumin concentrations and laser flare photometry in eyes with endogenous uveitis

Ophthalmologica. 1998;212(4):275-7. doi: 10.1159/000027306.

Abstract

Purpose: To assess the correlation between laser flare measurements and anterior chamber IgG/albumin concentrations in eyes with mild to severe inflammation.

Materials and methods: Seventeen eyes of 17 patients with endogenous uveitis underwent diagnostic paracentesis. IgG and albumin concentrations were determined from the samples of aqueous humor. Laser flare measurements were performed 1 h prior to paracentesis. The relationship between flare measurements and IgG/albumin concentrations was studied be plotting the data on a logarithmic scale.

Results: The flare measurement was 97.5+/-150.0 photons ms (mean +/- SD; range 4.3-528.7). The IgG concentration was 41.0+/-51.4 mg/dl mean +/- SD; range 0.2-200). The albumin concentration was 184.6+/-196.2 mg/dl (mean +/- SD; range 4-535). When plotted on a logarithmic scale, there was a statistically significant linear relationship between the flare measurements and the anterior chamber IgG or albumin concentrations (y = 1.14x-0.64, r= 0.87, p<0.001 for IgG; y = 1.39x-0.1, r= 0.94, p<0.001 for albumin).

Conclusion: Laser flare photometry is an accurate technique for assessing anterior chamber inflammation. Flare measurements strongly correlate with blood-aqueous barrier breakdown.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Albumins / metabolism*
  • Animals
  • Anterior Chamber / metabolism*
  • Aqueous Humor / metabolism
  • Biomarkers
  • Cats
  • Humans
  • Immunoglobulin G / metabolism*
  • Lasers
  • Middle Aged
  • Paracentesis
  • Photometry
  • Prospective Studies
  • Uveitis / diagnosis
  • Uveitis / etiology
  • Uveitis / metabolism*

Substances

  • Albumins
  • Biomarkers
  • Immunoglobulin G