Slowed information processing in HIV-1 disease. The Multicenter AIDS Cohort Study (MACS)

J Clin Exp Neuropsychol. 1998 Feb;20(1):60-72. doi: 10.1076/jcen.


This investigation examined the effects of HIV-1 infection on speeded complex cognitive processing in a group of HIV-negative (n = 666), HIV-positive symptomatic (n = 156), and HIV-positive asymptomatic (n = 623) participants while controlling for the effects of slowed motor functioning, peripheral neuropathy, and several other putative confounds. Stroop Interference and reaction-time tasks served as anchor procedures to assess cognitive processing. The present findings suggest that HIV-1 infection is capable of compromising CNS-mediated cognitive processes (speeded processing) infringing upon their efficacy in the symptomatic stages of the disease while sparing individuals in the asymptomatic stage. The detrimental effects observed on information-processing mechanisms associated with HIV infection persisted despite the use of procedures to control for peripheral nerve integrity and other potential confounds.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • AIDS Dementia Complex / diagnosis*
  • AIDS Dementia Complex / psychology
  • Adult
  • Attention*
  • Cohort Studies
  • Color Perception
  • Discrimination Learning
  • HIV-1*
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Neuropsychological Tests*
  • Problem Solving
  • Reaction Time*
  • Semantics