Chondrocalcin as a marker of articular cartilage degeneration in anterior cruciate ligament-deficient knees

Orthopedics. 1998 Jul;21(7):773-6. doi: 10.3928/0147-7447-19980701-06.


This study assessed articular cartilage deterioration and the effect of meniscal tears to evaluate the usefulness of chondrocalcin as a joint fluid marker in 43 patients with anterior cruciate ligament (ACL) deficiency. A significant correlation was found between the cartilage damage and time after injury. The high incidence of long longitudinal tears of the medial meniscus with increased cartilage damage, especially in chronic cases, suggests that this type of meniscal tear contributed to the deterioration of ACL-deficient knees. Chondrocalcin concentrations were found to have a significant correlation with cartilage damage.

MeSH terms

  • Adolescent
  • Adult
  • Anterior Cruciate Ligament Injuries*
  • Biomarkers
  • Calcium-Binding Proteins / metabolism*
  • Cartilage, Articular / pathology*
  • Collagen / metabolism*
  • Collagen Type II
  • Female
  • Humans
  • Knee Injuries / metabolism
  • Knee Injuries / pathology*
  • Male
  • Middle Aged
  • Statistics, Nonparametric
  • Tibial Meniscus Injuries
  • Time Factors


  • Biomarkers
  • Calcium-Binding Proteins
  • Collagen Type II
  • chondrocalcin
  • Collagen