Serum tumor necrosis factor in patients with gastric cancer

Anticancer Res. May-Jun 1998;18(3A):1597-9.

Abstract

We have measured serum TNF-alpha levels in 220 gastric cancer patients, 9 patients with gastric polyps or ulcers, 9 hepatitis B carriers and 85 normal controls. The results showed that no positive TNF-alpha value (> 10 pg/ml) was detected in Hepatitis B carriers and benign gastric lesions' patients and normal controls. In the cancer group, 17 out of 220 patients (7.7%) had positive-TNF-alpha values. The proportion of TNF-alpha positive was 6.8% in stage I disease, 6.5% in stage II disease, 3.7% stage III, and 12.9% stage IV. No clinicopathologic factors were related to positive TNF-alpha value. TNF-alpha value was not an independent prognostic indicator The role of TNF-alpha in gastric cancer remains obscures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aged
  • Carrier State
  • Female
  • Hepatitis B / blood
  • Hepatitis B / immunology
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Polyps / blood
  • Polyps / immunology
  • Polyps / surgery
  • Prognosis
  • Reference Values
  • Stomach Neoplasms / blood*
  • Stomach Neoplasms / immunology
  • Stomach Neoplasms / pathology
  • Stomach Neoplasms / surgery
  • Stomach Ulcer / blood
  • Stomach Ulcer / immunology
  • Tumor Necrosis Factor-alpha / analysis*
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Tumor Necrosis Factor-alpha