Efficacy of difloxacin in growing broiler chickens for the control of infection due to pathogenic Mycoplasma gallisepticum

Zentralbl Veterinarmed B. 1998 Jun;45(5):305-10. doi: 10.1111/j.1439-0450.1998.tb00798.x.


Chickens 14 days old were experimentally inoculated with Mycoplasma gallisepticum (MG) R-P10 strain. After development of respiratory symptoms, birds were left unmedicated or medicated for 5 consecutive days with Difloxacin 5, 7.5 or 10 mg/kg body weight per day or Enrofloxacin at the dose level of 10 mg/kg body weight per day. Evaluation of efficacy was based on body weight, symptoms, post-mortem findings, re-isolation of MG and serology. Results indicated that under the conditions of this experiment, treatment with 7.5 mg Difloxacin per kg body weight for 5 days was already effective against pathogenic MG infection. The dose of 10 mg/kg Difloxacin was equally effective as a dose of 10 mg/kg Enrofloxacin in treating respiratory symptoms.

MeSH terms

  • Animals
  • Anti-Infective Agents / therapeutic use*
  • Chickens
  • Ciprofloxacin / analogs & derivatives*
  • Ciprofloxacin / therapeutic use
  • Enrofloxacin
  • Female
  • Fluoroquinolones*
  • Male
  • Mycoplasma / isolation & purification
  • Mycoplasma Infections / prevention & control
  • Mycoplasma Infections / veterinary*
  • Poultry Diseases / prevention & control*
  • Quinolones / therapeutic use


  • Anti-Infective Agents
  • Fluoroquinolones
  • Quinolones
  • Enrofloxacin
  • Ciprofloxacin
  • difloxacin