Abstract
Continuous intravenous infusion of epoprostenol sodium in selected patients with primary pulmonary hypertension improves symptoms and survival. This report describes two patients with primary pulmonary hypertension treated with epoprostenol in whom intrapulmonary shunting and severe hypoxemia occurred. Intrapulmonary shunting was confirmed by contrast echocardiography showing delayed appearance of bubbles in the left cardiac chambers after peripheral venous injection of agitated saline solution.
MeSH terms
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Antihypertensive Agents / administration & dosage
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Antihypertensive Agents / therapeutic use*
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Contrast Media / administration & dosage
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Echocardiography
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Epoprostenol / administration & dosage
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Epoprostenol / therapeutic use*
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Hemangioma, Capillary / pathology
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Humans
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Hypertension, Pulmonary / drug therapy
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Hypertension, Pulmonary / physiopathology*
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Hypoxia / etiology
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Infusions, Intravenous
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Injections, Intravenous
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Lung Neoplasms / pathology
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Lung Transplantation
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Male
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Middle Aged
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Pulmonary Circulation / drug effects
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Pulmonary Circulation / physiology*
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Pulmonary Fibrosis / pathology
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Sodium Chloride / administration & dosage
Substances
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Antihypertensive Agents
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Contrast Media
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Sodium Chloride
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Epoprostenol