Existence of striatal nerve cells coexpressing CCK(B) and D2 receptor mRNAs

Neuroreport. 1998 Jun 22;9(9):2035-8. doi: 10.1097/00001756-199806220-00023.


Co-localization of CCK(B) and D2 receptor mRNAs was analysed in adjacent sections of nucleus caudate putamen of the rat by means of in situ hybridization. A distinct subpopulation of D2 mRNA containing striatal nerve cells (in the order of 10%) was shown to co-express CCK(B) and D2 receptor mRNAs. All the CCK(B) receptor mRNA-positive nerve cells were co-localized with D2 receptor mRNA. These results give one morphological substrate to the previously demonstrated CCK(B)/D2 receptor interactions in the striatum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autoradiography
  • In Situ Hybridization
  • Male
  • Neostriatum / cytology*
  • Neostriatum / metabolism*
  • Neurons / metabolism*
  • Putamen / metabolism
  • RNA Probes
  • RNA, Messenger / biosynthesis*
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Cholecystokinin / biosynthesis*
  • Receptors, Dopamine D2 / biosynthesis*


  • RNA Probes
  • RNA, Messenger
  • Receptors, Cholecystokinin
  • Receptors, Dopamine D2